Jiří Vohradský
Ing. Jiří Vohradský, PhD.
Inst. of Microbiology
Czech Academy of Sciences
Vídeňská 1083
142 20 Prague
Czech Republic
phone:(+420) 2 4106 2513
(+420) 2 9644 2513
fax: (+420) 2 4172 2257
vohr@biomed.cas.cz

Scope of research

Our main objective is to analyze, model, and simulate on computers regulatory processes in the cell, identify & predict function of non-coding RNAs, and provide bioinformatics support for measured data. We develop computerized deterministic and probabilistic models of regulation of gene expression and we use statistics and artificial intelligence for analysis of large scale gene expression data.

We computationally predict new ncRNAs and identify their function using structure similarity to already functionally characterized ncRNAs, employing the fact that function of biological molecules depends on their structure. In collaboration with Lab. of regulation of gen expression, we predict function of mRNA and rRNA in eukaryotic gene translation during which local, progressive structures of mRNA are formed and interact with molecules of the ribosome complex, and with rRNA.

The lab is divided into two parts – computational and a wet lab, which in collaboration with the lab of J. Bobek, Charles University, Prague, prepares most of the data processed in the lab.

For storage of large scale proteomics data we have established (originally with Biozentrum, Univ. Basel) a database and proteomics server SWICZ. The server hosts the databases for streptomycetes and caulobacter species, and is equipped with graphical interface and search engines which allow retrieving relevant information. The databases are linked with other data sources as GeneBank, and KEGG metabolic pathway server.

J. Vohradsky is involved in the coordination of the Czech division of the Large European infrastructure ELIXIR – European Life Science Infrastructure for Biological Information, part of ESFRI, ERIC.

The lab was a member of the consortium ActinoGEN of the EU 6th framework program .